Introduction: Glyceryl trinitrate (GTN) ointment (0· 2 per cent) has an efficacy of up to 68 per
cent in healing chronic anal fissure, but with headache as a major side‐effect. Diltiazem …

Background. Botulinum toxin induces healing in patients with idiopathic anal fissures.
Methods. One hundred-fifty patients with posterior anal fissures were treated with botulinum …

PURPOSE: Chronic anal fissure may be treated by chemical or surgical sphincterotomy. The
aim of this study was to test the efficacy of local application of nifedipine and lidocaine …

Background: The management of disorders of the lower gastrointestinal tract, such as
chronic anal fissure and pelvic floor dysfunction, has undergone re‐evaluation recently. To a …

Diseases of the rectum and anus are common, and the prevalence in the general population
is probably much higher than that seen in clinical practice since most patients with …

Background: Although lateral sphincterotomy heals chronic fissure in ano in over 90 per cent
of cases it is a surgical technique with inherent complications. To avoid such complications …

Purpose: As lateral sphincterotomy and anal dilatation causes complications, a reversible
chemical sphincterotomy method has been recently proposed as an alternative treatment in …

Objective The primary aim of this study was to assess the outcome of advancement
anoplasty in the treatment of chronic anal fissure, resistant to conventional therapy. The …

PURPOSE: Pharmacologic treatments are gaining widespread acceptance as first-line
therapy for anal fissure. However, existing treatments have limited clinical usefulness …

There are numerous definitive reviews concerning aetiology and management of acute and
chronic anal fissures. The problem of persistence and recurrence after surgical and …