Subcellular localization of nitric oxide (NO) synthases with effector molecules is an important
regulatory mechanism for NO signalling. In the heart, NO inhibits L-type Ca2+ channels but …

Objective: To test the hypothesis that, when measured in the long axis, left ventricular
systolic function is abnormal in patients with diastolic heart failure. Design: A case–control …

Objective: To evaluate whether or not “uncomplicated” obesity (without associated
comorbidities) is really associated with cardiac abnormalities. Research Methods and …

Abstract FK506 binding proteins 12 and 12.6 (FKBP12 and FKBP12. 6) are intracellular
receptors for the immunosuppressant drug FK506 (ref.). The skeletal muscle ryanodine …

Covering all aspects of electrocardiography, this comprehensive resource helps readers
picture the mechanisms of arrhythmias, their ECG patterns, and the options immediately …

Recent studies have identified key gender differences in cardiovascular function, renal
hemodynamics, and the renin-angiotensin system. Extensive epidemiologic evidence has …

Malmqvist K, Öhman KP, Lind L, Nyström F, Kahan T (Karolinska Institutet Danderyd
Hospital, Stockholm; Faculty of Health Sciences, Linköping; University Hospital, Uppsala …

A close relationship between abnormalities of the lipid metabolism and arterial hypertension
has been observed in several epidemiological studies. The aim of the present study was to …

Left ventricular hypertrophy (LVH) is a major cardiovascular risk factor for morbidity and
mortality. It is caused by arterial hypertension, although various hemodynamic and …

Background: It has been proposed that concentric left ventricular hypertrophy (LVH) is
related to a worse degree of target organ damage in hypertensives with this feature than in …