Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Lipoxins (LX) are trihydroxytetraene-containing eicosanoids that are generated within the
vascular lumen during platelet–leukocyte interactions and at mucosal surfaces via leukocyte …

The endothelium plays an important role in maintaining vascular homeostasis by
synthesizing and releasing several vasodilating factors, including prostacyclin, nitric oxide …

Cytochrome P450s metabolize arachidonic acid to hydroxyeicosatetraenoic acids and
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …

The soluble epoxide hydrolase (sEH) is involved in the metabolism of arachidonic, linoleic,
and other fatty acid epoxides, endogenous chemical mediators that play an important role in …

Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle are
mediated by endothelium-derived hyperpolarizing factors (EDHFs). EDHF candidates …

Vascular smooth muscle cell (SMC) migration and proliferation contribute to neointimal
hyperplasia and restenosis after vascular injury. The epoxyeicosatrienoic acids (EETs) …

Evidence is increasing in hypertensive models for an inflammatory reaction in the
microcirculation with abnormal leukocyte counts and adhesion to the endothelium …

CYP2J2 is abundant in cardiovascular tissue and active in the metabolism of arachidonic
acid to eicosanoids that possess potent anti-inflammatory, vasodilatory, and fibrinolytic …

P450-dependent arachidonic acid (AA) metabolites regulate arterial tone by modulating
calcium-activated (BK) potassium channels in vascular smooth muscle cells (VSMC) …