Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase
DG Hardie, DA Pan - Biochemical Society Transactions, 2002 - portlandpress.com
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy charge and a
'metabolic master switch'. When activated by ATP depletion, it switches off ATP-consuming …
'metabolic master switch'. When activated by ATP depletion, it switches off ATP-consuming …
Invited review: exercise training-induced changes in insulin signaling in skeletal muscle
JR Zierath - Journal of applied physiology, 2002 - journals.physiology.org
This review will provide insight on the current understanding of the intracellular signaling
mechanisms by which exercise training increases glucose metabolism and gene expression …
mechanisms by which exercise training increases glucose metabolism and gene expression …
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
DR Bolster, SJ Crozier, SR Kimball… - Journal of Biological …, 2002 - ASBMB
AMP-activated protein kinase (AMPK) is viewed as an energy sensor that acts to modulate
glucose uptake and fatty acid oxidation in skeletal muscle. Given that protein synthesis is a …
glucose uptake and fatty acid oxidation in skeletal muscle. Given that protein synthesis is a …
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
SA Hawley, AE Gadalla, GS Olsen, DG Hardie - Diabetes, 2002 - Am Diabetes Assoc
Metformin, a drug widely used to treat type 2 diabetes, was recently shown to activate the
AMP-activated protein kinase (AMPK) in intact cells and in vivo. In this study we addressed …
AMP-activated protein kinase (AMPK) in intact cells and in vivo. In this study we addressed …
The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
LGD Fryer, A Parbu-Patel, D Carling - Journal of Biological Chemistry, 2002 - ASBMB
AMP-activated protein kinase (AMPK) is activated within the cell in response to multiple
stresses that increase the intracellular AMP: ATP ratio. Here we show that incubation of …
stresses that increase the intracellular AMP: ATP ratio. Here we show that incubation of …
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
S Horman, GJ Browne, U Krause, JV Patel… - Current biology, 2002 - cell.com
Protein synthesis, in particular peptide-chain elongation, consumes cellular energy. Anoxia
activates AMP-activated protein kinase (AMPK, see [1]), resulting in the inhibition of …
activates AMP-activated protein kinase (AMPK, see [1]), resulting in the inhibition of …
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)
K Barnes, JC Ingram, OH Porras… - Journal of cell …, 2002 - journals.biologists.com
In the rat liver epithelial cell line Clone 9, the Vmax for glucose uptake is actuely increased
by inhibition of oxidative phosphorylation and by osmotic stress. By using a membrane …
by inhibition of oxidative phosphorylation and by osmotic stress. By using a membrane …
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
ES Buhl, N Jessen, R Pold, T Ledet, A Flyvbjerg… - Diabetes, 2002 - Am Diabetes Assoc
The insulin resistance syndrome is characterized by several risk factors for cardiovascular
disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine …
disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine …
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in ratskeletal …
JFP Wojtaszewski, SB Jørgensen, Y Hellsten… - Diabetes, 2002 - Am Diabetes Assoc
5′-AMP-activated protein kinase (AMPK) functions as a metabolic switch in mammalian
cells and can be artificially activated by 5-aminoimidazole-4-carboxamide (AICA)-riboside …
cells and can be artificially activated by 5-aminoimidazole-4-carboxamide (AICA)-riboside …
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells
LGD Fryer, F Foufelle, K Barnes, SA Baldwin… - Biochemical …, 2002 - portlandpress.com
Stimulation of AMP-activated protein kinase (AMPK) in skeletal muscle has been correlated
with an increase in glucose transport. Here, we demonstrate that adenoviral-mediated …
with an increase in glucose transport. Here, we demonstrate that adenoviral-mediated …