Patients with amyotrophic lateral sclerosis (ALS) invariably develop respiratory muscle
weakness and most die from pulmonary complications. There are numerous tests available …

Amyotrophic lateral sclerosis (ALS) is caused by a progressive degeneration of motor
neurons. The cause of sporadic ALS is not known, but 1–2% of all cases are familial and …

Nerve growth factor belongs to a small family of proteins whose binding at the Trk and
p75NTR transmembrane receptors triggers a cascade of signaling events that give rise to …

Preclinical neuroscience has advanced rapidly over the past two decades. New approaches
for treating neurological disease, including gene-based therapies, nervous-system growth …

Previous studies suggest that neurotrophins support regeneration and survival of injured
motoneurons. Based on these findings, brain-derived neurotrophic factor (BDNF) has been …

Certain neurotrophins promote or induce oxidative neuronal death in cortical cultures.
However, the effector mechanisms mediating this phenomenon have not been delineated. In …

We compared the clinical and pharmacodynamic effects of N-terminal methionine brain-
derived neurotrophic factor (met-BDNF) and endogenous met-free BDNF in wobbler mouse …

Although Forced Ventricular Capacity (FVC), 1 Tufts Quantitative Neuromuscular Evaluation
(TQNE), 2 megascores and functional rating scales3 have recently been used as endpoints …

In allen multizellulären Organismen wird die interzelluläre Interaktion durch
Wachstumsfaktoren kontrolliert und gesteuert. Seit der Entdeckung des nerve growth factor …

Spinal cord injury is a devastating disease that has eluded successful treatment. It has been
a long-held belief that most injuries are untreatable. This view is changing as new …