The nuclear factor-κB (NF-κB)/REL family of transcription factors has a central role in
coordinating the expression of a wide variety of genes that control immune responses. There …

The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …

Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …

The choice between life and death is one of the major events in regulation of the immune
system. T cells that specifically recognize viral or bacterial antigens are selected to survive …

The lymphotoxin-β receptor (LTβR) plays critical roles in inflammation and lymphoid
organogenesis through activation of NF-κB. In addition to activation of the classical NF-κB …

B-cell-activating factor of the tumour-necrosis-factor family (BAFF) enhances B-cell survival—
a function that is indispensable for B-cell maturation—and has a role in enhancing immune …

Recent advances in genomics and proteomics, combined with the facilitated generation and
analysis of transgenic and gene-knockout animals, have revealed new complexities in …

Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR)
signals to make crucial cell-fate decisions at several checkpoints during their development …

Transcription factors of the Rel/NF-κB family are activated in response to signals that lead to
cell growth, differentiation, and apoptosis, and these proteins are critical elements involved …

NF-κB is usually activated by signal-induced, ubiquitin-mediated degradation of its inhibitor,
IκB. This process is initiated by phosphorylation of IκB by the IκB kinase (IKK) complex …