▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Alterations in mitochondrial distribution and morphology are associated with normal cellular
processes such as cell division and differentiation, as well as a variety of pathological …

The cell biology of intermediate filament (IF) proteins and their filaments is complicated by
the fact that the members of the gene family, which in humans amount to at least 65, are …

Intermediate filament (IF) proteins form the largest family of cytoskeletal proteins in
mammalian cells. The function of these proteins has long been thought to be only structural …

Objective: Defects in mitochondrial structure and function have been found in association
with cardiovascular diseases such as dilated and hypertrophic cardiomyopathy, cardiac …

Mutations of the human plectin gene (Plec1) cause autosomal recessive epidermolysis
bullosa simplex with muscular dystrophy (EBS-MD). Here, we report on molecular …

The heart is highly dependent for its function on oxidative energy generated in mitochondria,
primarily by fatty acid beta-oxidation, respiratory electron chain and oxidative …

Mice lacking the intermediate filament protein desmin demonstrate abnormal mitochondria
behavior, disruption of muscle architecture, and myocardial degeneration with extensive …

Quantitative electron microscopy was used to characterize the longitudinal mobility of
myofibrils during muscle extension to investigate the functional roles of skeletal muscle …

In the heart, in situ local myocardial blood flow (MBF) varies greater than 10‐fold between
individual areas and displays a spatially heterogeneous pattern. To analyze its molecular …