Cyclin-dependent kinases as cellular targets for antiviral drugs

LM Schang - Journal of Antimicrobial Chemotherapy, 2002 - academic.oup.com
Cyclin-dependent kinases (cdks) are required for replication of viruses that replicate only in
dividing cells, such as adeno-and papillomaviruses. Recently, cdks have been shown to be …

Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells

D Delmas, P Passilly-Degrace… - International …, 2002 - spandidos-publications.com
Resveratrol is a natural polyphenolic compound produced by a number of plants and found
in high amount in peanuts, seeds, grapes or berries as source of human nutrition …

The subcellular localization of cyclin dependent kinase 2 determines the fate of mesangial cells: role in apoptosis and proliferation

K Hiromura, JW Pippin, MJ Blonski, JM Roberts… - Oncogene, 2002 - nature.com
Apoptosis is closely linked to proliferation. In this study we showed that inducing apoptosis
in mouse mesangial cells with ultraviolet (UV) irradiation was associated with increased …

A Tumor Cell Growth Inhibitor from Saposhnikovae divaricata

YC Kuo, YL Lin, CP Huang, JW Shu… - Cancer investigation, 2002 - Taylor & Francis
In the present study, we tested ethanolic extracts from 10 Chinese herbs for their effects on
K562, Raji, Wish, HeLa, Calu-1, and Vero tumor cells proliferation. On a percentage basis …

Molecular analysis on the chemopreventive properties of resveratrol, a plant polyphenol microcomponent

N Latruffe, D Delmas, B Jannin… - International …, 2002 - spandidos-publications.com
As a plant microcomponent, resveratrol is a polyphenolic compound produced by several
species and found especially in Polygonum roots, peanuts seeds, berries and also grape …

MyoD induces apoptosis in the absence of RB function through a p21WAF1-dependent re-localization of cyclin/cdk complexes to the nucleus

A Peschiaroli, R Figliola, L Coltella, A Strom… - Oncogene, 2002 - nature.com
During differentiation of skeletal myoblasts, MyoD promotes growth arrest through the
induction of the cdk inhibitor p21 and the accumulation of hypophosphorylated RB protein …

[HTML][HTML] Nuclear localization of CDC25B1 and serine 146 integrity are required for induction of mitosis

V Baldin, K Pelpel, M Cazales, C Cans… - Journal of Biological …, 2002 - ASBMB
CDC25B phosphatases are essential regulators that control cyclin-dependent kinases
activities at the entry into mitosis. In this study, we demonstrate that serine 146 is required for …

Sensitivity to growth suppression by 1α, 25-dihydroxyvitamin D3 among MCF-7 clones correlates with Vitamin D receptor protein induction

SS Jensen, MW Madsen, J Lukas, J Bartek… - The Journal of steroid …, 2002 - Elsevier
The antiproliferative effect of 1α, 25-dihydroxyvitamin D3 (1α, 25 (OH) 2D3) has been
studied for a decade in diverse model systems, but the signalling pathways linking 1α, 25 …

Ethanol differentially modulates the expression and activity of cell cycle regulatory proteins in rat aortic smooth muscle cells

S Sayeed, JP Cullen, M Coppage, JV Sitzmann… - European journal of …, 2002 - Elsevier
The aim of this study was to determine the effect of ethanol on cell cycle events during the
G1 and S phases in cultured vascular smooth muscle cells (VSMC). Flow cytometric analysis …

Isolated p27 protein

J Massague, JM Roberts, A Koff, K Polyak - US Patent 6,355,774, 2002 - Google Patents
An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular
weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E …