▪ Abstract Ovulation is a complex process that is initiated by the lutenizing hormone surge
and is controlled by the temporal and spatial expression of specific genes. This review …

The interactions of peptide and steroid hormone signaling cascades in the ovary are critical
for follicular growth, ovulation, and luteinization. Although the pituitary gonadotropins follicle …

The primary endocrine organs responsible for steroid hormone biosynthesis–the adrenal
cortex and gonads–are derived from the urogenital ridge. Several recent discoveries in …

Abstract Wnt ligands and Frizzled (Fz) G protein-coupled receptors impact cell fate, including
embryonic development of the ovary. Because the role of these regulatory molecules during …

In mammals, anti-Mullerian hormone (AMH) is produced by Sertoli cells from the onset of
testicular differentiation and by granulosa cells after birth. In birds, AMH starts to be …

Disorders of reproduction represent a significant social, medical, and economic burden for
individuals and society. Approximately 1 in 10 couples in the United States are infertile, and …

A review of the genetics of male undermasculinization must encompass a description of the
embryology of the genital system. The dimorphism of sex development consequent upon the …

Although gonads are not required for development or survival, defects in gonadal
development undoubtedly have a profound influence on affected individuals. Recent …

The acquisition of a sexually dimorphic phenotype is a key event in mammalian
development. The underlying principle of this essential process is that genetic sex …

The molecular mechanisms of gonadal development are a complex process, which involves
the tightly regulated differentiation of a bipotential embryonic gonad into either testes or …