Multiple neural systems controlling food intake and body weight

HR Berthoud - Neuroscience & Biobehavioral Reviews, 2002 - Elsevier
Discovery of the leptin receptor and its downstream peptidergic pathways has reconfirmed
the crucial role of the hypothalamus in the regulation of food intake and energy balance …

Orexins and appetite regulation

RJ Rodgers, Y Ishii, JCG Halford, JE Blundell - Neuropeptides, 2002 - Elsevier
Initial research on the functional significance of two novel hypothalamic neuropeptides,
orexin-A and orexin-B, suggested an important role in appetite regulation. Since then …

Orexins and the treatment of obesity

D Smart, AC Haynes, G Williams, JRS Arch - European journal of …, 2002 - Elsevier
Orexin-A and-B are two peptides derived by proteolytic cleavage from a 130-amino acid
precursor, prepro-orexin, which were recently isolated from the rat hypothalamus. Orexin-A …