Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

Abstract Cyclooxygenase‐2 (COX‐2) is the inducible isoform of cyclooxygenase, the
enzyme that catalyzes the rate‐limiting step in prostaglandin synthesis from arachidonic …

Abstract Cyclooxygenase-2 (COX-2) is expressed within neovascular structures that support
many human cancers. Inhibition of COX-2 by celecoxib delays tumor growth and metastasis …

Mortality that results from the common forms of cancer is still unacceptably high. Despite
immense advances in the understanding of the mechanisms of carcinogenesis, in bringing …

▪ Abstract Disease prevention is one area that both public and governmental agencies
strongly support owing to its potential for an improved lifestyle and a reduction in health care …

In addition to the well-established pathophysiological role that COX-2 plays in inflammation,
recent evidence implies that this isoform may also be involved in multiple biologic events …

Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

Hypoxia-induced up-regulation of vascular endothelial growth factor (VEGF) expression is a
critical event leading to tumor neovascularization. Hypoxia stimulates hypoxia-inducible …

More than half of all chronic cancer pain arises from metastases to bone, and bone cancer
pain is one of the most difficult of all persistent pain states to fully control. Several tumor …

Potential chemopreventive agents for colorectal cancer are assessed in rodents. We
speculated that the magnitude of the effect is meaningful and ranked all published agents …