KIR genes have evolved in primates to generate a diverse family of receptors with unique
structures that enable them to recognize MHC-class I molecules with locus and allele …

Optimal lymphocyte activation requires the simultaneous engagement of stimulatory and
costimulatory receptors. Stimulatory immunoreceptors are usually composed of a ligand …

Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical major
histocompatibility complex (MHC) class I molecule which presents a restricted set of …

NK cell activity is partially controlled through interactions between killer Ig-like receptors
(KIR) on NK cells and their respective HLA class I ligands. Independent segregation of HLA …

Natural killer cell (NK) receptors for major histocompatibility complex (MHC) class I influence
engraftment and graft-versus-tumor effects after allogeneic bone marrow transplantation. We …

Abstract Ly49 and CD94/NKG2 inhibitory receptors are predominantly expressed on murine
NK cells, but they are also expressed on a subpopulation of peripheral CD8 memory TCR …

Ly49A, an inhibitory C-type lectin-like mouse natural killer cell receptor, functions through
interaction with the major histocompatibility complex class I molecule, H-2D d. The x-ray …

Natural killer cell-associated direct cytotoxicity and cytokine production are crucial
mechanisms for early innate host resistance against viruses, bacteria, or protozoa. The …

NK cell function is regulated by a dual receptor system, which integrates signals from
triggering receptors and MHC class I‐specific inhibitory receptors. We show here that the src …

The cytotoxic activity of NK cells is regulated by class I MHC proteins. Although much has
been learned about NK recognition of class I autologous targets, the mechanisms of NK self …