RNA interference
GJ Hannon - nature, 2002 - nature.com
A conserved biological response to double-stranded RNA, known variously as RNA
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …
Gene silencing in mammals by small interfering RNAs
MT McManus, PA Sharp - Nature reviews genetics, 2002 - nature.com
Among the 3 billion base pairs of the human genome, there are∼ 30,000–40,000 protein-
coding genes, but the function of at least half of them remains unknown. A new tool—short …
coding genes, but the function of at least half of them remains unknown. A new tool—short …
RNA interference in adult mice
AP McCaffrey, L Meuse, TTT Pham, DS Conklin… - Nature, 2002 - nature.com
RNA interference is an evolutionarily conserved surveillance mechanism that responds to
double-stranded RNA by sequence-specific silencing of homologous genes. Here we show …
double-stranded RNA by sequence-specific silencing of homologous genes. Here we show …
[HTML][HTML] Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
H Zhang, FA Kolb, V Brondani, E Billy… - The EMBO …, 2002 - embopress.org
Dicer is a multi‐domain RNase III‐related endonuclease responsible for processing double‐
stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA …
stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA …
Genetic association studies: design, analysis and interpretation
CM Lewis - Briefings in bioinformatics, 2002 - academic.oup.com
This paper provides a review of the design and analysis of genetic association studies. In
case control studies, the different contingency tables and their relationships to the …
case control studies, the different contingency tables and their relationships to the …
siRNA-directed inhibition of HIV-1 infection
CD Novina, MF Murray, DM Dykxhoorn, PJ Beresford… - Nature medicine, 2002 - nature.com
RNA interference silences gene expression through short interfering 21–23-mer double-
strand RNA segments that guide mRNA degradation in a sequence-specific fashion. Here …
strand RNA segments that guide mRNA degradation in a sequence-specific fashion. Here …
Gene silencing using micro-RNA designed hairpins
During RNA interference (RNAi), long dsRNA is processed to∼ 21 nt duplexes, short
interfering RNAs (siRNAs), which silence genes through a mRNA degradation pathway …
interfering RNAs (siRNAs), which silence genes through a mRNA degradation pathway …
[HTML][HTML] Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy
T Tuschl, A Borkhardt - Molecular Interventions, 2002 - triggered.stanford.clockss.org
RNA interference (RNAi) represents an evolutionarily conserved cellular defense for
controlling the expression of foreign genes in most eukaryotes including humans. RNAi is …
controlling the expression of foreign genes in most eukaryotes including humans. RNAi is …
Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells
D Yang, F Buchholz, Z Huang, A Goga… - Proceedings of the …, 2002 - National Acad Sciences
Small interfering RNA (siRNA) has become a powerful tool for selectively silencing gene
expression in cultured mammalian cells. Because different siRNAs of the same gene have …
expression in cultured mammalian cells. Because different siRNAs of the same gene have …
Lentiviral-mediated RNA interference
T Abbas-Terki, W Blanco-Bose, N Déglon… - Human gene …, 2002 - liebertpub.com
RNA interference (RNAi) is a form of posttranscriptional gene silencing mediated by short
double-stranded RNA, known as small interfering RNA (siRNA). These siRNAs are capable …
double-stranded RNA, known as small interfering RNA (siRNA). These siRNAs are capable …