Obesity is often associated with the metabolic syndrome, which includes insulin resistance,
glucose intolerance and dyslipidemia. The best predictor of these morbidities is not the total …

Objective: To review recent advances in understanding the role of leptin in the physiology
and pathophysiology of reproduction, with a focus on relevant clinical situations. Design: A …

We previously showed that leptin inhibits bone formation by an undefined mechanism. Here,
we show that hypothalamic leptin-dependent antiosteogenic and anorexigenic networks …

Mice, and cattle with mutations in the myostatin (GDF8) gene show a marked increase in
body weight and muscle mass, indicating that this new member of the TGF-β superfamily is a …

Mice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and
resistant to obesity. However, the molecular basis for resistance to obesity has been unclear …

Obesity is a major risk factor for insulin resistance and type 2 diabetes mellitus. Adipocytes
secrete numerous substances that might contribute to peripheral insulin sensitivity. These …

Common obesity is primarily characterized by resistance to the actions of the hormone
leptin. Mice deficient in protein tyrosine phosphatase 1B (PTP1B) are resistant to diabetes …

Background: Obesity is a risk factor for breast cancer in postmenopausal women. As body
weight and fat mass increase, circulating leptin increases. Leptin is an adipocyte-derived …

Despite extensive studies implicating tumor necrosis factor (TNF)-α as a contributing cause
of insulin resistance, the mechanism (s) by which TNF-α alters energy metabolism in vivo …

Phenotypic plasticity is the extent to which an organism can change its physiology,
behaviour, morphology and/or development in response to environmental cues …