Many of the signaling pathways and regulatory systems in eukaryotic cells are controlled by
proteins with multiple interaction domains that mediate specific protein–protein and protein …

Two very similar H3 histones—differing at only four amino acid positions—are produced in
Drosophila cells. Here we describe a mechanism of chromatin regulation whereby the …

Recent studies of histone methylation have yielded fundamental new insights pertaining to
the role of this modification in gene activation as well as in gene silencing. While a number …

The nuclear hormone receptor co‐activator CARM1 has the potential to methylate histone
H3 at arginine residues in vitro. The methyltransferase activity of CARM1 is necessary for its …

Background: Dynamic changes in the modification pattern of histones, such as acetylation,
phosphorylation, methylation, and ubiquitination, are thought to provide a code for the …

The PWWP domain is a weakly conserved sequence motif found in> 60 eukaryotic proteins,
including the mammalian DNA methyltransferases Dnmt3a and Dnmt3b. These proteins …

The literature on intracellular signal transduction presents a confusing picture: every
regulatory factor appears to be regulated by all signal transduction cascades and to regulate …

Histone N-terminal tails are post-translationally modified in many ways. At lysine residues,
histones can be either acetylated or methylated. Both modifications lead to the binding of …

Antibodies to histone deacetylases (HDACs) have been used to immuno-isolate
deacetylase complexes from HeLa cell extracts. Complexes shown to contain HDAC1 …

Silent information regulator 2 (Sir2) family of enzymes has been implicated in many cellular
processes that include histone deacetylation, gene silencing, chromosomal stability, and …