Endothelial cells consist of a heterogeneous population covering the entire inner surface of
blood vessels. This review will focus on the factors influencing this heterogeneity …

Tumor-stroma interactions play a significant role in tumor development and progression.
Alterations in the stromal microenvironment, including enhanced vasculature …

The enzyme endothelial nitric oxide synthase (eNOS) is essential for vascular integrity.
Many studies have demonstrated a link between the localization and activity of eNOS. Here …

Lumen formation is a fundamental step in the development of the structural and functional
units of glandular organs, such as alveoli and ducts. In an attempt to elucidate the molecular …

Solid cancers must stimulate expansion of the vascular network for continued growth. The
process of angiogenesis involves endothelial cell migration so as to reorganize into vessel …

Aims: intimal hyperplasia is mediated by smooth muscle cell proliferation, migration and
deposition of extracellular matrix. The anti-fibrotic agent pirfenidone has been shown to …

Conclusions The above summarized findings of this laboratory on tumor-stroma interactions,
together with a growing number of other reports contribute to the accumulating evidence that …

Sažetak Urokinase plasminogen activator (uPA) and its inhibitors (PAI) are elements of
plasminogen activation system, a proteolytic system involved in many physiological and …

Serine serine that play a variety of physiological roles in vivo. 1-3 Not all molecules
proteases are termed serpins. But all serpins have a that inhibit very special protein structure …

Acquisition of invasive/metastatic potential through protease expression is a key event in
tumor progression. The proteolytic enzyme plasmin is generated from the precursor …