Tumor suppressor genes in normal and malignant hematopoiesis

U Krug, A Ganser, HP Koeffler - Oncogene, 2002 - nature.com
Over the last decade, a growing number of tumor suppressor genes have been discovered
to play a role in tumorigenesis. Mutations of p53 have been found in hematological …

Effect of flavonoids on cell cycle progression in prostate cancer cells

T Kobayashi, T Nakata, T Kuzumaki - Cancer letters, 2002 - Elsevier
The effect of some flavonoids, which are components of fruits, vegetables, and peas, on the
cell cycle progression of human LNCaP prostate cancer cells has been investigated in this …

Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: induction of tryptophan oxygenase

A Kamiya, N Kojima, T Kinoshita, Y Sakai, A Miyaijma - Hepatology, 2002 - Elsevier
Previously, we described that embryonic day 14.5 (E14. 5) mouse fetal hepatocytes
differentiate to express tyrosine amino transferase (TAT) and glucose-6-phosphatase, which …

Activation of the Drosophila MLK by ceramide reveals TNF-α and ceramide as agonists of mammalian MLK3

P Sathyanarayana, MK Barthwal, CN Kundu, ME Lane… - Molecular cell, 2002 - cell.com
Mixed lineage kinases (MLKs) are MAPKKK members that activate JNK and reportedly lead
to cell death. However, the agonist (s) that regulate MLK activity remain unknown. Here, we …

IL-1β during in vitro decidualization in primate

Z Strakova, S Srisuparp, AT Fazleabas - Journal of reproductive …, 2002 - Elsevier
The sequence of biochemical and molecular events associated with decidualization in the
primate remain unclear. In the baboon, the sequential changes during this period in vivo are …

Downregulation of c-Jun expression by transcription factor C/EBPα is critical for granulocytic lineage commitment

J Rangatia, RK Vangala, N Treiber… - … and cellular biology, 2002 - Taylor & Francis
The transcription factor C/EBPα is crucial for the differentiation of granulocytes. Conditional
expression of C/EBPα triggers neutrophilic differentiation, and C/EBPα can block 12-O …

Morphological changes induced by extracellular matrix are correlated with maturation of rat small hepatocytes

S Sugimoto, T Mitaka, S Ikeda, K Harada… - Journal of cellular …, 2002 - Wiley Online Library
Small hepatocytes (SHs), which are known to be hepatic progenitor cells, were isolated from
an adult rat liver. SHs in a colony sometimes change their shape from small to large and …

Integrins α6Aβ1 and α6Bβ1 promote different stages of chondrogenic cell differentiation

D Segat, R Comai, E Di Marco, A Strangio… - Journal of Biological …, 2002 - ASBMB
The differentiation of chondrocytes and of several other cell types is associated with a switch
from the α 6B to the α 6A isoform of the laminin α 6 β 1 integrin receptor. To define whether …

Type I collagen inhibits hydroxyl radical-induced apoptosis

Y He, J Chen, J Ren, G Wang… - The journal of …, 2002 - academic.oup.com
The extracellular matrix (ECM) plays an important role in cell differentiation and apoptosis.
Collagen is the major component of ECM. Here, an ESR signal of the hydroxyl radicals …

Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell

FM Boyce - US Patent 6,338,962, 2002 - Google Patents
Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a
mammalian cell, involving introducing into the cell a non-mammalian DNA virus (eg, a …