Alzheimer's disease (AD) is a progressive, neurodegenerative disorder characterized by
amyloid deposition in the cerebral neuropil and vasculature. These amyloid deposits …

Alzheimer's disease (AD) is the most common cause of dementia that arises on a
neuropathological background of amyloid plaques containing β-amyloid (Aβ) derived from …

The deposition of the abundant presynaptic brain protein α-synuclein as fibrillary aggregates
in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders …

Abstract α-Synucleinopathies are neurodegenerative disorders that range pathologically
from the demise of select groups of nuclei to pervasive degeneration throughout the …

Parkinson's disease is a movement disorder characterized by degeneration of dopaminergic
neurons in the substantia nigra pars compacta. Dopaminergic neuronal loss also occurs in …

The substantia nigra is not the induction site in the brain of the neurodegenerative process
underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 …

Recombinant adeno-associated viral vectors display efficient tropism for transduction of the
dopamine neurons of the substantia nigra. Taking advantage of this unique property of …

Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of
pedigrees with familial PD. Moreover, α-Syn accumulates as a major component of Lewy …

α-Synuclein is the major component of Lewy bodies and Lewy neurites, which are granular
and filamentous protein inclusions that are the defining pathological features of several …

α-Synuclein-containing aggregates represent a feature of a variety of neurodegenerative
disorders, including Parkinson's disease (PD). However, mechanisms that promote …