Fertilization is one of the most specific and carefully regulated cell-cell interactions in the
animal body and is determined to a large extent by compatibility between ligand and …

The roles of acrosomal matrix proteases in sperm–zona pellucida interactions have long
been one of the most puzzling questions in mammalian fertilization. Of the acrosomal …

To identify novel human sperm membrane antigens, we analyzed two-dimensional gels of
sperm extracts containing hydrophobic proteins that partitioned into Triton X-114. Four …

We have previously described the zonae pellucidae (ZP) binding ability of a pig sperm
surface protein, P68. Our recent results on peptide sequencing of 3 P68 tryptic peptides and …

Publisher Summary This chapter summarizes the functions of the sperm acrosome while
assessing the currently accepted model for the states of the acrosome during fertilization …

Despite the importance of fertilization for controlling human reproduction, regulating animal
production, and promoting preservation of endangered species, the molecular basis …

We report an inhibitory effect of an anti-actin monoclonal antibody (mAb) on the human zona
pellucida (ZP)-induced acrosome reaction (AR). Motile sperm were incubated with native …

There is considerable evidence that mouse fertilization requires the binding of sperm to two
of the three glycoproteins that form the zona pellucida (ZP), ZP3 and ZP2. Despite the …

In order to evaluate the immunocontraceptive potential of zona pellucida (ZP) glycoproteins,
recombinant bonnet monkey (Macaca radiata) zona pellucida glycoprotein-1 (r-bmZP1) and …

Fertilization is defined as a series of gametic interactions in which capacitated sperm must
first penetrate the egg vestments and then bind to and fuse with the egg plasma membrane …