There is a pressing need for treatments for neurodegenerative diseases. Hopes have been
raised by the prospect of neural stem cell therapy; however, despite intense research …

Neural stem cells (NSCs) have great potential as a therapeutic tool for the repair of a
number of CNS disorders. NSCs can either be isolated from embryonic and adult brain …

In the adult brain, new neurons are continuously generated in the subventricular zone and
dentate gyrus, but it is unknown whether these neurons can replace those lost following …

Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that
synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify …

The adult brain is extremely vulnerable to various insults. The recent discovery of neural
progenitors in adult mammals, however, raises the possibility of repairing damaged tissue …

Objective: To test the effect of IV-injected human bone marrow stromal cells (hMSC) on
neurologic functional deficits after stroke in rats. Methods: Rats were subjected to transient …

Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients,
current methods are rudimentary, and a reliable donor cell source is lacking. We show that …

There is now evidence to suggest that bone marrow mesenchymal stem cells (MSCs) not
only differentiate into mesodermal cells, but can also adopt the fate of endodermal and …

In Parkinson's disease, progressive loss of dopaminergic neurons in the substantia nigra
pars compacta (SN) leads to debilitating motor dysfunction. One current therapy aims at …

We investigated the hypothesis that neural stem cells (NSCs) possess an intrinsic capacity
to “rescue” dysfunctional neurons in the brains of aged mice. The study focused on a …