Pax6 is a highly conserved gene that controls eye development in all species where it has
been tested. In spite of this common 'master control regulator', the eyes of different animals …

We identified mutations in the VSX1 homeobox gene for two distinct inherited corneal
dystrophies; posterior polymorphous dystrophy (PPD) and keratoconus. One of the mutation …

In Xenopus, the Mix/Bix family of homeobox genes has been implicated in mesendoderm
development. Mixl1 is the only known murine member of this family. To examine the role of …

The Staphylococcus aureus multidrug‐binding protein QacR represses transcription of the
qacA multidrug transporter gene and is induced by multiple structurally dissimilar drugs …

We have discovered an unusual homeodomain protein, called HOP, which is comprised
simply of a homeodomain. HOP is highly expressed in the developing heart where its …

We have carried out a genome-wide screen for novel N-ethyl-N-nitrosourea-induced
mutations that give rise to eye and vision abnormalities in the mouse and have identified 25 …

Crx (cone-rod homeobox) is a homeodomain transcription factor implicated in regulating the
expression of photoreceptor and pineal genes. To identify proteins that interact with Crx in …

PAX6 functions as a transcription factor and has two DNA-binding domains, a paired domain
(PD) and a homeodomain (HD), joined by a glycine-rich linker and followed by a proline …

Animal studies have recently shed a considerable amount of light on the normal
development of the forebrain and pituitary gland. There is now good evidence that anterior …

Interactions between proteins, drugs, water and B-DNA minor groove have been analyzed in
crystal structures of 60 protein–DNA and 14 drug–DNA complexes. It was found that only …