Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
GE Meredith, S Totterdell, E Petroske, K Santa Cruz… - Brain research, 2002 - Elsevier
We have detected granular and filamentous inclusions that are alpha-synuclein-and
ubiquitin-immunoreactive in the cytoplasm of dopaminergic and cortical neurons of …
ubiquitin-immunoreactive in the cytoplasm of dopaminergic and cortical neurons of …
Glial cell response: a pathogenic factor in Parkinson's disease
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) …
progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) …
Calpain upregulation and neuron death in spinal cord of MPTP‐induced parkinsonism in mice
B Chera, KE Schaecher, A Rocchini… - Annals of the New …, 2002 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disorder resulting in slowness, tremors,
and imbalance. Treatment of mice with 1‐methyl‐4‐phenyl‐1, 2, 3, 6 tetrahydropyridine …
and imbalance. Treatment of mice with 1‐methyl‐4‐phenyl‐1, 2, 3, 6 tetrahydropyridine …
Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice
Apomorphine has been introduced in the treatment of late-stage Parkinson's Disease (PD).
The disadvantage of a short half-life of apomorphine is now overcome by the use of a …
The disadvantage of a short half-life of apomorphine is now overcome by the use of a …
Molecular and cellular events regulating dopamine neuron survival
GU Corsini, R Maggio, F Vaglini - Dopamine in the CNS II, 2002 - Springer
The progressive degeneration of dopamine (DA)-melanized neurons of the substantia nigra
pars compacta (SNpc) represents the pathological hallmark of Parkinson's disease (PD) …
pars compacta (SNpc) represents the pathological hallmark of Parkinson's disease (PD) …