Asthma, one of the most common chronic diseases, is a complex and heterogeneous
disorder. The results of genome screens for asthma-related traits in 11 different populations …

Asthma is the most common chronic childhood disease in developed nations and is a
complex disease that has high social and economic costs. Asthma and its associated …

Asthma is a common respiratory disease that is characterized by variable airways
obstruction caused by acute and chronic bronchial inflammation; associated phenotypes …

Background: A substantial body of evidence exists to support the pivotal role of IL-13 in the
pathogenesis of bronchial asthma. We recently found that a variant of the IL13 gene …

Asthma and eczema (atopic dermatitis) are characterized by a number of unexplained
phenomena: the familial aggregation of disease, the initiation of disease by apparently trivial …

The world‐wide effort to identify susceptibility genes for allergic diseases is motivated by the
conviction that the identification of disease genes may permit the design of new classes of …

Studies in both humans and mice clearly show that interleukin (IL)-13 is a central regulator
of allergic inflammation. Numerous single nucleotide polymorphisms have been recently …

Abstract Interleukin 13 (IL-13) has been demonstrated to have a crucial role in animal
models of allergy and asthma. In human case-control genetic-association studies, the …

Current asthma therapy is directed at the relief of chronic inflammation or improving lung
function through bronchodilation. These approaches treat the overt symptoms of asthma but …

THE ROLE OF AIRWAY SMOOTH MUSCLE in asthma has been appreciated for some time.
In 1859, Salter (12) wrote:“the phenomena of asthma–the distressing sensation and the …