Inflammation has always been thought of as detrimental in the pathophysiology of multiple
sclerosis (MS). However, emerging genetic data, magnetic-resonance-imaging studies, and …

Evidence is mounting that genetic variation influences not only susceptibility to multiple
sclerosis (MS), but also its course and severity. Identification of disease modifying genes …

Background: The association between multiple sclerosis and class II alleles of the major
histocompatibiliy complex, in particular the DRB1* 1501-DQB1* 0602 haplotype, is well …

Multiple sclerosis is a clinically heterogeneous demyelinating disease and an important
cause of acquired neurological disability. An underlying complex genetic susceptibility plays …

Background Immune-mediated demyelination and axonal damage lead to early functional
impairment in multiple sclerosis (MS). Ciliary neurotrophic factor (CNTF) is a potent survival …

The aim of this study was to determine the role of the HLA-DRB1 gene [6p21] in
susceptibility to juvenile MS (JMS)(age at onset≤ 15 years) of children of Russian descent …

Association of multiple sclerosis (MS) with the human leukocyte antigen (HLA) class II
haplotype DRB1* 1501-DQB1* 0602 is the most consistently replicated finding of genetic …

We analyzed the HLA class II haplotypes in 249 Finnish nuclear families and compared the
frequencies of parental haplotypes transmitted or non-transmitted to multiple sclerosis (MS) …

Genetic factors influence susceptibility to multiple sclerosis but the responsible genes
remain largely undefined, association with MHC class II alleles being the only established …

Recent advances in our knowledge of the natural history of multiple sclerosis deal with the
influence of pregnancy and vaccination, the predictive value of magnetic resonance imaging …