Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Opioid peptides and their G-protein-coupled receptors (δ, κ μ) are located in the central
nervous system and peripheral tissues. The opioid system has been studied to determine …

The catabolism of the endomorphins was investigated in detail. The endomorphins were
degraded relatively slowly in the rat brain homogenate (t1/2 (endomorphin-1)= 4.94 min; t1/2 …

Endomorphin (EM)‐1 and EM‐2 are tetrapeptides with high affinity and selectivity for the μ‐
opioid receptor. We have utilized specific radioimmunoassays to characterize EM‐1 and EM …

Two highly selective m-opioid receptor agonists, endomorphin-1 (EM-1) and endomorphin-2
(EM-2), have been identified and postulated to be endogenous m-opioid receptor ligands …

Hormones strongly influence and even" drive" certain primitive behaviors. In Central Neural
States Relating Sex and Pain, Richard J. Bodnar, Kathryn Commons, and Donald W. Pfaff …

The present study characterizes the relationship between the endogenous mu opioid
peptides endomorphin‐1 (EM‐1) and endomorphin‐2 (EM‐2) and several splice variants of …

Endomorphin-2 is a newly discovered endogenous opioid peptide with high affinity and
selectivity for the μ-opioid receptor, and potent analgesic activity, particularly in the spinal …

To determine if different subtypes of μ-opioid receptors were involved in antinociception
induced by endomorphin-1 and endomorphin-2, the effect of pretreatment with various μ …

The aim of the present investigations was to characterize the effect of endomorphins on the
function of rat small intestine smooth muscle and on the electrically induced ascending and …