Transgenic animals have been used for years to study gene function and to create models
for the study of human diseases. This approach has become still more justified after the …

Translocation of Sleeping Beauty (SB) transposon requires specific binding of SB
transposase to inverted terminal repeats (ITRs) of about 230bp at each end of the …

Gene therapy applications of naked DNA constructs for genetic disorders have been limited
because of lack of permanent transgene expression. This limitation, however, can be …

Gene transfer to generate transgenic animals is used more and more to study gene
regulation and function. It is also an essential tool to prepare pharmaceuticals or pig organs …

Dictyostelium discoideum is a eukaryotic microorganism that is attractive for the study of
fundamental biological phenomena such as cell-cell communication, formation of …

The need for genetically engineered animals for drug target discovery, development and
validation is growing. Transgenic animals, including mice and rats, and knockout and knock …

Gene therapy applications of naked DNA constructs for genetic disorders have been limited
because of lack of permanent transgene expression. Thislimitation, however, can be …

Double-strand RNA (dsRNA) induced specific mRNA degradation, also known as RNA
interference (RNAi), is a recently recognized phenomenon conserved among eukaryotic …