Sulfonylureas are widely used to treat type 2 diabetes because they stimulate insulin
secretion from pancreatic β-cells. They primarily act by binding to the SUR subunit of the …

Glucose homeostasis is of paramount concern to the brain since glucose is its primary fuel.
Thus, the brain has evolved mechanisms to sense and respond to changes in glucose …

Suppression of M current channels by muscarinic receptors enhances neuronal excitability.
Little is known about the molecular mechanism of this inhibition except the requirement for a …

Inwardly rectifying K+(Kir) channels are important regulators of resting membrane potential
and cell excitability. The activity of Kir channels is critically dependent on the integrity of …

Reaction to stress requires feedback adaptation of cellular functions to secure a response
without distress, but the molecular order of this process is only partially understood. Here …

Glucose‐responsive (GR) neurons from hypothalamic nuclei are implicated in the regulation
of feeding and satiety. To determine the role of intracellular ATP in the closure of ATP …

Using patch clamp techniques, we found that the epithelial sodium channel (ENaC) activity
in the apical membrane of A6 distal nephron cells showed a sudden rundown beginning at 4 …

Phosphatidylinositol 4, 5-biphosphate (PIP2) modulates the function of numerous ion
transporters and channels, as well as cell signaling and cytoskeletal proteins. To study PIP2 …

Transduction of metabolic signals is essential in preserving cellular homeostasis. Yet,
principles governing integration and synchronization of membrane metabolic sensors with …

▪ Abstract ATP-binding cassette (ABC) transporters located in the hepatocyte canalicular
membrane of mammalian liver are critical players in bile formation and detoxification …