The plasminogen system has been implicated in clot lysis, wound healing, tissue
regeneration, cancer and many other processes that affect health and disease. The …

Degradation of extracellular matrix is crucial for malignant tumour growth, invasion,
metastasis and angiogenesis. Matrix metalloproteinases (MMPs) are a family of zinc …

Angiogenesis, the formation of blood vessels from a pre-existing vasculature, is a process
whereby capillary sprouts are formed in response to externally supplied chemical stimuli …

The role of intracellular proteases (eg, calpains and caspases) in the pathophysiology of
neuronal cell death has been extensively investigated. More recently, accumulating data …

Cathepsin-D is an independent marker of poor prognosis in human breast cancer. We
previously showed that human wild-type cathepsin-D, as well as its mutated form devoid of …

Although many studies have focused on blood vessel development and new blood vessel
formation associated with disease processes, the question of how endothelial cells (ECs) …

The process of angiogenesis is a dynamic one. Vascular endothelial cells are changing at
the same time the extracellular matrix is being remodeled. Stupack and Cheresh discuss …

Physiological angiogenesis occurs during embryogenesis, wound healing and reproductive
functions in adults. Abnormal angiogenesis takes place in certain chronic diseases …

Angiogenesis, a key step in many physiological and pathological processes, involves
proteolysis of the extracellular matrix. To study the role of two enzymatic families, serine …

The “macrophage balance hypothesis” was proposed in the early 1990s to depict the
complex relationship that tumor-associated macrophages (TAM) have with the neoplastic …