▪ Abstract Nearly twenty years after the first high-resolution crystal structures of specific
protein-DNA complexes were determined, the stereo-chemical basis for protein-DNA …

Solvent binding in the nucleosome core particle containing a 147 base pair, defined-
sequence DNA is characterized from the X-ray crystal structure at 1.9 Å resolution. A single …

This book provides a detailed view of the molecular structures of DNA and RNA and how
they are recognised by small molecules and proteins. Extensive source material is provided …

The initiation of DNA replication is a key event in the cell cycle of all organisms. In bacteria,
replication initiation occurs at specific origin sequences that are recognized and processed …

Osmotic pressure and hydrostatic pressure can be used effectively to probe the behavior of
biologically important macromolecules and their complexes. Using the two techniques …

The widespread use of the maize Mutator (Mu) system to generate mutants exploits the
preference of Mu transposons to insert into genic regions. However, little is known about the …

Noncovalent association of proteins to specific target sites on DNA—a process central to
gene expression and regulation—has thus far proven to be idiosyncratic and elusive to …

Interactions between proteins, drugs, water and B-DNA minor groove have been analyzed in
crystal structures of 60 protein–DNA and 14 drug–DNA complexes. It was found that only …

The tryptophan biosynthesis genes of several Bacilli are controlled through terminator/anti-
terminator transcriptional attenuation. This process is regulated by tryptophan-dependent …

The comparison of homologous noncoding DNA for organisms a suitable evolutionary
distance apart is a powerful tool for the identification of cis regulatory elements for …