Purpose: Breast cancer in men is uncommon; 1500 new cases are diagnosed in the United
States yearly. Optimal management of breast cancer in men is unknown because the rarity …

It is estimated that familial aggregation and genetic susceptibility play a role in as many as
10% of pancreatic ductal adenocarcinomas. To investigate the role of germ-line mutations in …

A family history of ovarian cancer confers an increased risk of ovarian cancer. We review the
literature quantifying the familial risks associated with ovarian cancer and assess the …

The etiology of RCC is incompletely understood and the inherited genetic contribution
uncertain. Although there are rare mendelian forms of RCC stemming from inherited …

Objective: To estimate the risk of malignant diseases in families of probands with the same
mutation in the BRCA2 gene. Design: A cohort study using record linkage of a breast cancer …

The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only
account for a minority of the familial aggregation of the disease. A recent study of 77 multiple …

In many developed countries, prostate cancer is the most frequently diagnosed malignancy
in men. The extent to which the marked racial/ethnic difference in its incidence rate is …

Background Breast cancer is the most common female malignancy and a major cause of
death in middle-aged women. So far, germline mutations in the BRCA1 and BRCA2 genes …

Background Hereditary predisposition to breast and ovarian cancer, most commonly due to
germline mutations in BRCA1 and BRCA2, has been recognized for many years. The …

An increasing number of studies indicates that the strength and even direction of association
between breast cancer and established risk factors differ according to the woman's age …