In the clinical setting, drug concentrations in cerebrospinal fluid (CSF) are sometimes used
as a surrogate for drug concentrations at the target site within the brain. However, the brain …

Cerebral malaria is a major killer in the developing world, but we still know very little about
the causes of this disease. How does Plasmodium falciparum cause such a devastating …

Formation of cerebral oedema caused by vascular leakage is a major problem in various
injuries of the CNS, such as stroke, head injury and high‐altitude illness. A common feature …

High-intensity focused ultrasound (HIFU) has been shown to generate lesions that destroy
brain tissue while disrupting the blood-brain barrier (BBB) in the periphery of the lesion. BBB …

Many diseases share the common feature of vascular leakage, and endothelial barrier
dysfunction is often the underlying cause. The subsequent stages of endothelial barrier …

Objective: The relationship between cerebral perfusion pressure (CPP) and cerebral blood
flow is unclear in preeclampsia. Our objective was to clarify this issue by comparing normal …

Bradykinin, an endogenous nonapeptide produced by activation of the kallikrein–kinin
system, promotes neuronal tissue damage as well as disturbances in blood–brain barrier …

Feline leukemia virus (FeLV) infection is associated with distinct neoplastic, hematologic,
and immunosuppressive diseases. Here we report on a novel neurologic syndrome in 16 …

In patients with severe liver failure, brain edema is a frequent and serious complication that
may result in high intracranial pressure and brain damage. This short article focuses on …

Hypertension is closely associated with vascular endothelial dysfunction. The aim of this
study was to investigate the effects of Angiotensin II (ANG II) receptor antagonist losartan on …