During the last decade, rigorous scientific methods have been applied to determine the
effects of cannabinoids on nociceptive neurotransmission. Cannabinoids have been …

Analgesia is an important physiological function of the endocannabinoid system and one of
significant clinical relevance. This review discusses the analgesic effects of …

A large body of literature indicates that cannabinoids suppress behavioral responses to
acute and persistent noxious stimulation. This review examines behavioral …

Cannabinoids have previously been shown to possess analgesic properties in a model of
visceral hyperalgesia in which the neurotrophin, nerve growth factor (NGF), plays a pivotal …

The brain produces at least five compounds that possess sub-micromolar affinity for
cannabinoid receptors: anandamide, 2-arachidonoylglycerol, noladin ether, virodhamine …

Several lines of evidence show that endogenous and exogenous cannabinoids modulate
pain transmission at the spinal level through specific cannabinoid-1 (CB1) receptors. Since …

Cannabinoids are involved in the control of pain at the spinal level through the cannabinoid
receptor-1 (CB1) localized pre-and postsynaptically on primary afferent fibres and dorsal …

Five major approaches have been employed to determine the role of endocannabinoids in
pain modulation:(1) studies of various markers of endocannabinoid action aimed at …

Cannabinoids act at receptors on peripheral and central neurons to modulate diverse
physiological functions and produce analgesia. Corneal sensory nerves express the CB1 …

The method of c-fos immunodetection was used to map the distributions of neurons in the
lumbar spinal dorsal horn that were activated following intracutaneous (ic) microinjection, or …