DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis
C Bernstein, H Bernstein, CM Payne… - … Research/Reviews in …, 2002 - Elsevier
Two systems are essential in humans for genome integrity, DNA repair and apoptosis. Cells
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in …
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in …
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling
M Los, M Mozoluk, D Ferrari… - Molecular biology of …, 2002 - Am Soc Cell Biol
Death ligands not only induce apoptosis but can also trigger necrosis with distinct
biochemical and morphological features. We recently showed that in L929 cells CD95 …
biochemical and morphological features. We recently showed that in L929 cells CD95 …
The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly (ADP-ribose) polymerase activation and cell death in cortical culture
In the present study, we examined the role and the mechanism of poly (ADP-ribose)
polymerase (PARP) and poly (ADP-ribose) glycohydrolase (PARG) activation in zinc …
polymerase (PARP) and poly (ADP-ribose) glycohydrolase (PARG) activation in zinc …
Poly (ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation
G Szabó, S Bährle, N Stumpf, K Sonnenberg… - Circulation …, 2002 - Am Heart Assoc
The aim of the present study was to investigate the effects of the novel poly (ADP-ribose)
polymerase (PARP) inhibitor PJ34 (N-(6-oxo-5, 6-dihydro-phenanthridin-2-yl)-N, N …
polymerase (PARP) inhibitor PJ34 (N-(6-oxo-5, 6-dihydro-phenanthridin-2-yl)-N, N …
WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia …
K Wosikowski, K Mattern, I Schemainda, M Hasmann… - Cancer research, 2002 - AACR
We recently developed a class of novel antitumor agents that elicit a potent growth-inhibitory
response in many tumor cells cultured in vitro. WK175, a member of this class, was chosen …
response in many tumor cells cultured in vitro. WK175, a member of this class, was chosen …
PARP as a drug target for the therapy of diabetic cardiovascular dysfunction.
C Szabó - Drug news & perspectives, 2002 - europepmc.org
Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and a growing family of additional, novel poly (ADP-ribosylating) …
consisting of PARP-1 and a growing family of additional, novel poly (ADP-ribosylating) …
Poly (ADP-ribose) polymerase activation and cell injury in the course of rat heart heterotopic transplantation
C Fiorillo, S Pace, V Ponziani, C Nediani… - Free radical …, 2002 - Taylor & Francis
Free radicals and other reactive species generated during reperfusion of ischemic tissues
may cause DNA damage and, consequently, the activation of the nuclear enzyme poly (ADP …
may cause DNA damage and, consequently, the activation of the nuclear enzyme poly (ADP …
[图书][B] PARP as a Therapeutic Target
J Zhang - 2002 - books.google.com
Recent research in cell death mechanism has rekindled interest in PARP's [Poly (ADP-
Ribose) Polymerase] intriguing role in necrosis and apoptosis. PARP as a Therapeutic …
Ribose) Polymerase] intriguing role in necrosis and apoptosis. PARP as a Therapeutic …
Crystallization and preliminary X-ray analysis of human nicotinamide mononucleotide adenylyltransferase (NMNAT)
E Werner, M Ziegler, F Lerner… - … Section D: Biological …, 2002 - journals.iucr.org
Nicotinamide mononucleotide adenylyltransferase catalyses the final step in the synthesis of
nicotinamide-adenine dinucleotide (NAD+) by transferring the adenylyl moiety of ATP to …
nicotinamide-adenine dinucleotide (NAD+) by transferring the adenylyl moiety of ATP to …
PARP inhibitors as neuroprotective agents for brain injury
JH Greenberg, MC LaPlaca… - PARP as a Therapeutic …, 2002 - taylorfrancis.com
During cerebral ischemia and trauma, a complex cascade of events is set in motion that
contributes to cellular injury. When cerebral blood flow falls to levels of approximately 20 …
contributes to cellular injury. When cerebral blood flow falls to levels of approximately 20 …