The trypanosomiases
MP Barrett, RJS Burchmore, A Stich, JO Lazzari… - The Lancet, 2003 - thelancet.com
The trypanosomiases consist of a group of important animal and human diseases caused by
parasitic protozoa of the genus Trypanosoma. In sub-Saharan Africa, the final decade of the …
parasitic protozoa of the genus Trypanosoma. In sub-Saharan Africa, the final decade of the …
Chemotherapy of human African trypanosomiasis: current and future prospects
AH Fairlamb - Trends in parasitology, 2003 - cell.com
Three of the four currently approved drugs for the treatment of African trypanosomiasis
(sleeping sickness) were developed over 50 years ago. All of the current therapies are …
(sleeping sickness) were developed over 50 years ago. All of the current therapies are …
Treatment perspectives for human African trypanosomiasis
B Bouteille, O Oukem, S Bisser… - Fundamental & clinical …, 2003 - Wiley Online Library
Human African trypanosomiasis (HAT), or sleeping sickness, is currently on the rise. HAT
develops in two stages, the first involving the hemolymphatic system, and the second, the …
develops in two stages, the first involving the hemolymphatic system, and the second, the …
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis
AJ Nok - Parasitology research, 2003 - Springer
Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, has
remained a disease with no effective treatment. Recent progress in HAT research suggests …
remained a disease with no effective treatment. Recent progress in HAT research suggests …
[图书][B] Handbook of drugs for tropical parasitic infections
U Hellgren, O Ericsson, LL Gustafsson - 2003 - taylorfrancis.com
Parasitic infections such as malaria, schistosomiasis, trypanosomiasis and onchoceriasis
are the scourge of the tropical countries. Many of the drugs used for the treatment of tropical …
are the scourge of the tropical countries. Many of the drugs used for the treatment of tropical …
Intrathecal immune response pattern for improved diagnosis of central nervous system involvement in trypanosomiasis
V Lejon, H Reiber, D Legros, N Djé… - The Journal of …, 2003 - academic.oup.com
Diagnosis of central nervous system (CNS) involvement in human African trypanosomiasis
is crucial in determination of therapy. Cerebrospinal fluid (CSF) and serum immunoglobulin …
is crucial in determination of therapy. Cerebrospinal fluid (CSF) and serum immunoglobulin …
Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the …
V Jamonneau, P Solano, A Garcia… - Tropical Medicine & …, 2003 - Wiley Online Library
In human African trypanosomiasis (HAT), two disease stages are defined: the first, or haemo‐
lymphatic stage, and the second, or meningo‐encephalitic stage. Stage determination forms …
lymphatic stage, and the second, or meningo‐encephalitic stage. Stage determination forms …
Neuro-inflammatory risk factors for treatment failure in “early second stage” sleeping sickness patients treated with pentamidine
V Lejon, D Legros, A Savignoni, MG Etchegorry… - Journal of …, 2003 - Elsevier
In a clinical trial on efficacy of Pentamidine in second stage Trypanosoma brucei gambiense
patients with≤ 20 cells/μl in cerebrospinal fluid (CSF), 43% of treatment failures were …
patients with≤ 20 cells/μl in cerebrospinal fluid (CSF), 43% of treatment failures were …
[PDF][PDF] In vitro and in vivo models for the identification and evaluation of drugs active against Trypanosoma and Leishmania
SL Croft, R Brun - Drugs against parasitic diseases: R&D methodologies …, 2003 - tdr.who.int
In vitro assays and animal models have been developed to determine the activity of
compounds or drug formulations against Leishmania spp., Trypanosoma cruzi and …
compounds or drug formulations against Leishmania spp., Trypanosoma cruzi and …