Resuscitation can exacerbate cellular injury caused by hemorrhagic shock, and the type of
fluid used for resuscitation may play an important role in this injury. Unlike some factors in …

Abdominal compartment syndrome (ACS) has emerged to be a significant problem in
patients who develop postinjury multiple organ failure (MOF). Current laboratory research …

SummaryBackground and objective: The advantages of albumin over less costly alternative
fluids continue to be debated. Meta-analyses focusing on survival have been inconclusive …

Background This study reviews the efficacy of vacuum-assisted wound closure (VAWC) to
obtain primary fascial closure of open abdomens after severe trauma. Methods The study …

Background Hypertonic saline (HTS) attenuates polymorphonuclear neutrophil (PMN)-
mediated tissue injury after hemorrhagic shock. We hypothesized that HTS resuscitation …

The systemic inflammation that occurs in shock states is believed to promote overexuberant
microcirculatory activation, the release of toxic proteases and oxygen radicals causing …

Objective To evaluate novel indications for the use of human albumin solutions in the
prevention and treatment of acute lung injury following shock/resuscitation and to test the …

Objective Hypotension and hypoperfusion during septic shock may contribute to tissue
hypoxia and the intramyocardial inflammatory response that results in myocardial …

Background: Resuscitation fluids can have variable effects on key functions of circulating
polymorphonuclear neutrophils (PMNs) such as oxidative burst, chemotaxis, and bacterial …

Background We previously demonstrated that HBOC-201 is an efficient resuscitation fluid.
However, little is known about its immunomodulatory effects. The goal of this study was to …