Histone deacetylases (HDACs): characterization of the classical HDAC family
Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …
influenced by the post-translational modification of histones, the building blocks of …
Histone deacetylase in carcinogenesis and its inhibitors as anti-cancer agents
DH Kim, MJ Kim, HJ Kwon - BMB Reports, 2003 - koreascience.kr
The acetylation state of histone is reversibly regulated by histone acetyltransferase (HAT)
and deacetylase (HDAC). An imbalance of this reaction leads to an aberrant behavior of the …
and deacetylase (HDAC). An imbalance of this reaction leads to an aberrant behavior of the …
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen …
RR Rosato, JA Almenara, S Grant - Cancer research, 2003 - AACR
Abstract Effects of the histone deacetylase (HDAC) inhibitor MS-275 have been examined in
human leukemia and lymphoma cells (U937, HL-60, K562, and Jurkat) as well as in primary …
human leukemia and lymphoma cells (U937, HL-60, K562, and Jurkat) as well as in primary …
Molecular sequelae of histone deacetylase inhibition in human malignant B cells
N Mitsiades, CS Mitsiades… - Blood, The Journal …, 2003 - ashpublications.org
Histone acetylation modulates gene expression, cellular differentiation, and survival and is
regulated by the opposing activities of histone acetyltransferases (HATs) and histone …
regulated by the opposing activities of histone acetyltransferases (HATs) and histone …
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
MJ Peart, KM Tainton, AA Ruefli, AE Dear, KA Sedelies… - Cancer research, 2003 - AACR
Histone deacetylase inhibitors (HDACIs) are a new class of chemotherapeutic drugs able to
induce tumor cell apoptosis and/or cell cycle arrest; however, the molecular mechanisms …
induce tumor cell apoptosis and/or cell cycle arrest; however, the molecular mechanisms …
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
L Catley, E Weisberg, YT Tai, P Atadja, S Remiszewski… - Blood, 2003 - ashpublications.org
Histone deacetylase (HDAC) inhibitors are emerging as a promising new treatment strategy
in hematologic malignancies. Here we show that NVP-LAQ824, a novel hydroxamic acid …
in hematologic malignancies. Here we show that NVP-LAQ824, a novel hydroxamic acid …
[HTML][HTML] The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
JMA Moreira, P Scheipers, P Sørensen - BMC cancer, 2003 - Springer
Abstract Background Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of
core histones modulating chromatin structure and affecting gene expression. These …
core histones modulating chromatin structure and affecting gene expression. These …
Histone acetylation-mediated regulation of genes in leukaemic cells
AE Chambers, S Banerjee, T Chaplin, J Dunne… - European journal of …, 2003 - Elsevier
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) functions are associated
with various cancers, and the inhibition of HDAC has been found to arrest disease …
with various cancers, and the inhibition of HDAC has been found to arrest disease …
Inhibitors of histone deacetylase
D Delorme, R Ruel, R Lavoie, C Thibault… - US Patent …, 2003 - Google Patents
The invention relates to the inhibition of histone deacety lase. The invention provides
compounds and methods for inhibiting histone deacetylase enzymatic activity. The inven …
compounds and methods for inhibiting histone deacetylase enzymatic activity. The inven …
Histone Deacetylase Inhibitors Induce Growth Suppression and Cell Death in Human Rhabdomyosarcoma in Vitro
MC Kutko, RD Glick, LM Butler, DC Coffey… - Clinical cancer …, 2003 - AACR
Purpose: A group of histone deacetylase inhibitors has been shown to be effective in
suppressing the growth of a variety of transformed cell lines in vitro and in vivo. The effects of …
suppressing the growth of a variety of transformed cell lines in vitro and in vivo. The effects of …