Within the suprachiasmatic nucleus (SCN) of the mammalian hypothalamus is a circadian
pacemaker that functions as a clock. Its endogenous period is adjusted to the external 24-h …

The circadian clock provides a temporal structure that modulates biological functions from
the level of gene expression to performance and behaviour. Pioneering work on the fruitfly …

Experimental data on the circadian (≈ 24-h) clock in mammalian cells are vast, diverse, and
detailed. Mathematical models are therefore needed to piece these data together and to …

Light is a prominent stimulus that synchronizes endogenous circadian rhythmicity to
environmental light/dark cycles. Nocturnal light elevates mRNA of the Period1 (Per1) gene …

The suprachiasmatic nucleus (SCN) is the neuroanatomical locus of the mammalian
circadian pacemaker. Here we demonstrate that an abrupt shift in the light/dark (LD) cycle …

The circadian clock nucleus of the mammalian brain is composed of thousands of oscillator
neurons, each driven by the cell-autonomous action of a defined set of circadian clock …

The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm
researchers over several decades. Behavioral, genetic, and molecular studies helped to …

Aging alters numerous aspects of circadian biology, including the amplitude of rhythms
generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central …

A large number of physiological variables display 24-h or circadian rhythms. Genes
dedicated to the generation and regulation of physiological circadian rhythms have now …

The central circadian clock in mammals is housed in the brain and is based on cyclic
transcription and translation of clock proteins. How the central clock regulates peripheral …