Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …

▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate
in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which …

Mammalian promoters belong to two different categories in terms of base composition and
DNA methylation. In humans and mice, approximately 60% of all promoters colocalize with …

DNA methylation inhibits gene expression in animal cells, probably by affecting chromatin
structure. Biochemical studies suggest that this process may be mediated by methyl-specific …

Genomic imprinting relies on establishing and maintaining the parental-specific methylation
of DNA elements that control the differential expression of maternal and paternal alleles …

The androgen-androgen receptor (AR) signaling pathway plays a key role in proper
development and function of male reproductive organs, such as prostate and epididymis, as …

Infection with genital human papillomaviruses (HPVs) is the primary cause of cervical
cancer. The infection is widespread, and little is known about the secondary factors …

DNA methylation is a focus of epigenetic research in the immune system. This overview
begins with a synopsis of the players and processes involved in DNA methylation …

Aberrant DNA methylation of promoter CpG islands is associated with transcriptionally
repressive heterochromatin in neoplasia. The dynamics of this epigenetic process in …

ARHI is a maternally imprinted tumor suppressor gene that maps to a site on chromosome
1p31 where loss of heterozygosity has been observed in 40% of human breast and ovarian …