Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
H Jaeschke - American Journal of Physiology …, 2003 - journals.physiology.org
Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with
liver surgery under total vascular exclusion or after liver transplantation. The …
liver surgery under total vascular exclusion or after liver transplantation. The …
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury
H Jaeschke, JJ Lemasters - Gastroenterology, 2003 - Elsevier
Warm and cold hepatic ischemia followed by reperfusion leads to necrotic cell death
(oncosis), which often occurs within minutes of reperfusion. Recent studies also suggest a …
(oncosis), which often occurs within minutes of reperfusion. Recent studies also suggest a …
Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection
NC Teoh, GC Farrell - Journal of gastroenterology and …, 2003 - Wiley Online Library
This review highlights recent advances in our understanding of mechanisms underlying
reperfusion injury to the liver after warm hepatic ischemia. Sinusoidal endothelial cells and …
reperfusion injury to the liver after warm hepatic ischemia. Sinusoidal endothelial cells and …
Protective strategies against ischemic injury of the liver
N Selzner, H Rudiger, R Graf, PA Clavien - Gastroenterology, 2003 - Elsevier
This article summarizes strategies to protect the liver from injuries caused by ischemia and
reperfusion. Three different sections (ie, surgical and pharmacologic strategies and gene …
reperfusion. Three different sections (ie, surgical and pharmacologic strategies and gene …
Ischemic preconditioning protects from hepatic ischemia/reperfusion-injury by preservation of microcirculation and mitochondrial redox-state
M Glanemann, B Vollmar, AK Nussler, T Schaefer… - Journal of …, 2003 - Elsevier
Background/Aims: Ischemic preconditioning (IP) is known to protect hepatic tissue from
ischemia–reperfusion injury. However, the mechanisms involved are not fully understood …
ischemia–reperfusion injury. However, the mechanisms involved are not fully understood …
Current progress in the understanding of and therapeutic strategies for ischemia and reperfusion injury of the liver
S Arii, K Teramoto, T Kawamura - Journal of hepato-biliary-pancreatic …, 2003 - Springer
Ischemia and reperfusion (IR) injury of the liver consists of two distinct phases. The first
phase is caused by acute cellular injury at 3 to 6 h postreperfusion, which may be mainly …
phase is caused by acute cellular injury at 3 to 6 h postreperfusion, which may be mainly …
Role of reactive oxygen species in hepatic ischemia-reperfusion injury and preconditioning
H Jaeschke - Journal of Investigative Surgery, 2003 - Taylor & Francis
Ischemia–reperfusion injury is the main cause of primary dysfunction or nonfunction after
liver transplantation. In addition, the liver suffers from warm ischemia–reperfusion injury …
liver transplantation. In addition, the liver suffers from warm ischemia–reperfusion injury …
Platelet–endothelial cell interactions during hepatic ischemia–reperfusion in vivo: a systematic analysis
A Khandoga, P Biberthaler, K Messmer… - Microvascular …, 2003 - Elsevier
Platelets have been implicated in the pathophysiology of ischemia–reperfusion (I/R) injury.
This study was designed to analyze platelet–endothelial cell interactions after I/R of the liver …
This study was designed to analyze platelet–endothelial cell interactions after I/R of the liver …
Cytokine cascades and the hepatic inflammatory response to ischemia and reperfusion
T Okaya, AB Lentsch - Journal of Investigative Surgery, 2003 - Taylor & Francis
Ischemia/reperfusion injury of the liver has two distinct phases that contribute to hepatocyte
damage. The acute phase is characterized by Kupffer cell production of reactive oxygen …
damage. The acute phase is characterized by Kupffer cell production of reactive oxygen …
Protection against post-ischemic mitochondrial injury in rat liver by silymarin or TUDC
Background: Hepatic ischemia/reperfusion (I/R) injury is characterized by features such as
cholestasis. Mitochondria become susceptible to damage during ischemia and after …
cholestasis. Mitochondria become susceptible to damage during ischemia and after …