Preferentially expressed antigen of melanoma (PRAME) in the development of diagnostic and therapeutic methods for hematological malignancies

M Matsushita, R Yamazaki, H Ikeda… - Leukemia & …, 2003 - Taylor & Francis
PRAME (Preferentially expressed antigen of melanoma), highly expressed in various solid
tumor cells and normal testis, was first isolated as a human melanoma antigen recognized …

Novel targeted and immunotherapeutic strategies in chronic myeloid leukemia

J Schwartz, J Pinilla-Ibarz, RR Yuan… - Seminars in …, 2003 - Elsevier
The advanced understanding of the molecular biology and immunology of chronic myeloid
leukemia (CML) has led to novel therapeutic strategies unique to this disease. CML …

The abl/bcr gene product as a novel leukemia-specific antigen: peptides spanning the fusion region of abl/bcr can be recognized by both CD4+ and CD8+ T …

WM Wagner, Q Ouyang, G Pawelec - Cancer Immunology …, 2003 - Springer
Chronic myelogenous leukemia (CML) is characterized by a reciprocal translocation leading
to the Philadelphia chromosome. Two fusion genes are created by this translocation: bcr/abl …

[PDF][PDF] Synthetic peptides derived from the Wilms' tumor 1 protein sensitize human T lymphocytes to recognize chronic myelogenous leukemia cells

L Müller, A Knights, G Pawelec - The Hematology Journal, 2003 - researchgate.net
The Wilms' tumour 1 (WT1) molecule was screened in silico for the presence of 15-mer
sequences predicted to bind HLA-DRB1* 0401 (www. syfpeithi. de). Two peptides with the …

Immunization of Patients with Malignant Melanoma with Autologous CD34+ Cell-Derived Dendritic Cells Transduced Ex Vivo with a Recombinant Replication …

M Di Nicola, C Carlo-Stella, A Anichini… - Human gene …, 2003 - liebertpub.com
Study Design: Nonrandomized, noncontrolled, single center Study Objectives: Primary
objective: Define the safety and toxicity of DCs/MVA-hTyr vaccine in patients with …

Role of CD4+ T lymphocytes in antitumor immunity

É Rajnavölgyi, Á Lányi - Advances in cancer research, 2003 - Elsevier
Publisher Summary This chapter discusses the role of CD4+ T lymphocytes in antitumor
immunity, which recognize peptides of exogenous proteins in the context of major …

蛋白转导域介导BCR/ABL 抗原对CML 患者T 细胞的活化作用

刘强, 梁英民, 郑瑾, 李学义, 陈任安, 蒋姗姗… - 细胞与分子免疫学 …, 2003 - cqvip.com
目的: 研究蛋白转导域(PTD) 介导的BCR/ABL 抗原对慢性髓细胞白血病(CML) 患者T
细胞的特异性活化作用. 方法: 利用基因工程技术, 将PTD 基因与CML b3a2 bcr/abl …

Dendritic Cells: Immunobiology and Potential Use for Cancer Immunotherapy

D Avigan - … Stem Cell Transplantation: Clinical Research and …, 2003 - Springer
Dendritic cells (DCs) represent a complex network of antigen-presenting cells that play a
crucial role in the initiation of primary immunity as well as maintaining the balance between …

New Antigens and Avenues to Immunotherapy of Cancer

JL Schultze - Transplantation in Hematology and Oncology II, 2003 - Springer
Tumor immunology has seen many exciting developments in the last few years. In addition
to tumor antigens that are defined by anti-tumor T and B cell responses in patients the …

[引用][C] Autologous Hematopoietic Cell Transplantation for Chronic Myeloid Leukemia

R Bhatia, PB Mcglave - Thomas' Hematopoietic Cell …, 2003 - Wiley Online Library
Autologous Hematopoietic Cell Transplantation for Chronic Myeloid Leukemia Page 1 CML and
discuss novel strategies under development to improve results from this procedure. Rationale …