Each of the human CD1 proteins takes a different route through secretory and endocytic
compartments before finally arriving at the cell surface, where these proteins present …

Modification in the function of dendritic cells (DC), such as that achieved by microbial stimuli
or T cell help, plays a critical role in determining the quality and size of adaptive responses …

A major group of murine NK T (NKT) cells express an invariant Vα14Jα18 TCR α-chain
specific for glycolipid Ags presented by CD1d. Murine Vα14Jα18+ account for 30–50% of …

Natural killer T (NKT) cells are thought to be involved in innate responses against infection.
We investigated one specific type of NKT cell, Vα24/Vβ11 double positive, in hepatitis C …

Here we show that patients with myelodysplastic syndromes (MDS) have a severe
deficiency of glycolipid reactive Vα24+/Vβ11+ natural killer T (NKT) cells, but not NK cells or …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is accompanied
by the emergence of autoreactive T cells and a reduction in regulatory T cells. Humans and …

CD1d tetramers loaded with α-galactosylceramide (α-GalCer) bind selectively to mouse
invariant Vα14 (Vα14i) NKT cells and their human counterparts. Whereas tetramer binding …

1. Fowlkes BJ, Kruisbeek AM, Ton-That H, Weston MA, Coligan JE, Schwartz RH, Pardoll
DM. 1987. A novel population of T-cell receptor alpha beta-bearing thymocytes which …

Human CD1d-restricted natural killer T (NKT) cells, which are postulated to regulate the
immune response in several clinical settings, can be activated by α-galactosylceramide (α …

Atopic dermatitis (AD) is a common inflammatory skin disease. In AD, cytokines such as
interleukin (IL)-4 or interferon (IFN)-γ are considered to affect the disease status. Recently …