Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in
target tissue metabolic activation of xenobiotic compounds. They may also determine drug …

There is increasing information available on the existence of polymorphisms in genes
encoding xenobiotic metabolizing enzymes and the functional significance of many of these …

In the decade since their discovery, the two major breast cancer susceptibility genes BRCA1
and BRCA2, have been shown conclusively to be involved in a significant fraction of families …

Abstract Cytochrome P4501A1 (CYP1A1), which is involved in the metabolic activation of
polycyclic aromatic hydrocarbon procarcinogens derived from tobacco smoke, is induced in …

Abstract Objective: Cytochrome P450 1A1 plays a major role in the bioactivation of a number
of tobacco procarcinogens. Much interest has focused on a polymorphism in exon 7 of the …

CYP3A5 is the major CYP3A form in the human lung, and it is inducible by dexamethasone
in the human A549 lung adenocarcinoma cell line. In the present study, we characterized …

The contributions of different enzymes to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) biotransformation were assessed in human lung microsomes prepared from …

Cytochrome P450 (CYP) drug metabolising enzymes CYP1A1 and CYP1B1 are regulated
through the ligand-activated aryl hydrocarbon (Ah) receptor. Differential expression of …

Xenobiotic metabolizing Cytochrome P450 (P450) enzymes were investigated in
leukapheresed samples from 50 human individuals. It was the aim of the study (a) to get …

One kind of defense mechanism against development of cancer involves activities of a
series of enzymes that metabolize and excrete potentially toxic compounds and repair subtle …