Degenerative diseases of the brain were long considered among the most obscure and
intractable of human maladies. However, recent advances in understanding their …

▪ Abstract Intensive studies of three proteins—Presenilin, Notch, and the amyloid precursor
protein (APP)—have led to the recognition of a direct intersection between early …

We often think of neurodevelopmental disorders as beginning before birth, and many
certainly do. A handful, however, strike many months after birth, following a period of …

Background: Three causative genes have been identified for autosomal dominant AD.
Objective: To determine the proportion of patients with early onset AD with a positive family …

Sequences and structures of all P-loop-fold proteins were compared with the aim of
reconstructing the principal events in the evolution of P-loop-containing kinases. It is shown …

The cleavage of Notch by presenilin (PS)/γ-secretase is a salient example of regulated
intramembrane proteolysis, an unusual mechanism of signal transduction. This cleavage is …

Alzheimer's disease (AD) is the most common type of dementia in the elderly population.
Three genes have been identified as responsible for the rare early-onset familial form of the …

Alzheimer's disease (AD) is caused by the cerebral deposition of β-amyloid (Aβ), a 38–43-
amino acid peptide derived by proteolytic cleavage of the amyloid precursor protein (APP) …

Several lines of evidence indicate that alterations in axonal transport play a critical role in
Alzheimer's disease (AD) neuropathology, but the molecular mechanisms that control this …

There is compelling evidence that the etiology of Alzheimer's disease (AD) involves
characteristic amyloid-β (Aβ) deposition, oxidative stress, and anomalous metal–Aβ protein …