Regulators of G protein signaling (RGS) modulate heterotrimeric G proteins in part by
serving as GTPase-activating proteins for Gα subunits. We examined a role for RGS9-2, an …

G protein-activated K+ channels (Kir3 or GIRK) are activated by direct binding of Gβγ. The
binding sites of Gβγ in the ubiquitous GIRK1 (Kir3. 1) subunit have not been unequivocally …

Whole cell current and voltage clamp techniques were used to examine the properties of
acetylcholine‐sensitive K+ current (IKACh) in myocytes from adult mouse atrium …

G protein‐gated inwardly rectifying potassium (GIRK) channels are found in neurons, atrial
myocytes and neuroendocrine cells. A characteristic feature is their activation by stimulation …

G protein-gated inwardly rectifying K+ (Kir) channels are found in neurones, atrial myocytes,
and endocrine cells and are involved in generating late inhibitory postsynaptic potentials …

G protein βγ subunits bind and activate G protein-coupled inward rectifier K+ (GIRK)
channels. This protein-protein interaction is crucial for slow hyperpolarizations of cardiac …

Traditionally the consequences of activation of G-protein-coupled receptors (GPCRs) by an
agonist are studied using biochemical assays. In this study we use live cells and take …

The βγ subunits of G proteins modulate inwardly rectifying potassium (GIRK) channels
through direct interactions. Although GIRK currents are stimulated by mammalian Gβγ …

G-Protein activated, inwardly rectifying potassium channels (GIRKs) are important effectors
of G-protein β/γ-subunits, playing essential roles in the humoral regulation of cardiac activity …

This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors,
purified mammalian SNORF25 receptors, vectors comprising nucleic acid encod ing …