[HTML][HTML] G-proteins as transducers in transmembrane signalling

S Offermanns - Progress in biophysics and molecular biology, 2003 - Elsevier
The G-protein-mediated signalling system has evolved as one of the most widely used
transmembrane signalling mechanisms in mammalian organisms. All mammalian cells …

Participation of adenosine receptors in neuroprotection.

JA Ribeiro, AM Sebastiao… - Drug news & …, 2003 - europepmc.org
Adenosine is released from most cells, including neurons and glial cells. Once in the
extracellular space, adenosine modifies cell functioning by operating G-protein-coupled …

Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites

N Lindgren, A Usiello, M Goiny… - Proceedings of the …, 2003 - National Acad Sciences
Dopamine D2 receptors are highly expressed in the dorsal striatum where they participate in
the regulation of (i) tyrosine hydroxylase (TH), in nigrostriatal nerve terminals, and (ii) the …

Adaptations in adenosine signaling in drug dependence: therapeutic implications

SP Hack, MJ Christie - Critical Reviews™ in Neurobiology, 2003 - dl.begellhouse.com
Adenosine is an important endogenous purine neuromodulator in the central nervous
system that modulates many important cellular processes in neurons. The physiological …

Immunolocalization of multiple Gα subunits in mammalian spermatozoa and additional evidence for Gαs

RW Baxendale, LR Fraser - Molecular Reproduction and …, 2003 - Wiley Online Library
Like somatic cells, mammalian spermatozoa appear to contain several different
heterotrimeric G protein α‐subunits that could mediate specialized cell responses. However …

Amygdaloid D1 receptors are not linked to stimulation of adenylate cyclase

SK Leonard, CM Anderson, JE Lachowicz… - Synapse, 2003 - Wiley Online Library
In contrast to the classic signal transduction of D1 dopamine receptors in striatum or
molecular expression systems, it has been reported that D1 receptor agonists do not …

[图书][B] Structural mechanisms underlying ligand recognition and activation of the D (1)-like dopamine receptors

AK Jassen - 2003 - search.proquest.com
The D 1-like dopamine receptors (D 1/D 1A and D 5/D 1B) have been implicated in the
etiology of, and as therapeutic targets for, a wide variety of neurological and psychiatric …