Cancer is a highly variable disease with multiple heterogeneous genetic and epigenetic
changes. Functional studies are essential to understanding the complexity and …

The protein (MDM2) coded by the mouse double minute-2 (mdm2) gene or its human
homologue is well known as an oncoprotein. Malignant human tumors particularly breast …

Expression profiling has demonstrated that transcriptomes of primary malignancies differ
from those in normal tissue. It is unknown, however, whether there exist “surrogate” …

Even the first expression profiling studies of breast cancers have generated new insights.
They suggest for example, that information about tumor aggressiveness, prognosis …

Purpose: To provide practical considerations for diagnosing, counseling, and managing
patients at high risk for hereditary breast cancer. Design: We have studied 98 extended …

Cancer is a complex genetic disease characterized by the accumulation of multiple
molecular alterations. Current diagnostic and prognostic classifications, based on clinical …

We evaluated the potential utility of occult circulating tumor DNA as a molecular marker of
disease in subjects previously diagnosed with breast cancer. Using 24 microsatellite …

The more profound understanding of the genetics and molecular pathways driving human
tumorigensis is paralleled by an ongoing interest to translate this knowledge into …

Visualization enables us to find structures, features, patterns, and relationships in a dataset
by presenting the data in various graphical forms with possible interactions. A visualization …

We studied the expression profiles of total RNA in three types of human tissues. Reverse
transcription was performed on total RNA samples extracted from kidney, normal breast, and …