DNA methylation and cancer therapy
M Szyf - Drug Resistance Updates, 2003 - Elsevier
Vertebrate DNA is modified by methyl moieties at the 5′-position of cytosine rings residing
in the di-nucleotide sequence CpG. Approximately 80% of CpG dinucleotide sequences are …
in the di-nucleotide sequence CpG. Approximately 80% of CpG dinucleotide sequences are …
A Dnmt2-like protein mediates DNA methylation in Drosophila
N Kunert, J Marhold, J Stanke, D Stach, F Lyko - 2003 - journals.biologists.com
The methylation status of Drosophila DNA has been discussed controversially over a long
time. Recent evidence has provided strong support for the existence of 5-methylcytosine in …
time. Recent evidence has provided strong support for the existence of 5-methylcytosine in …
Epigenomic stress response: knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes
S Milutinovic, Q Zhuang, A Niveleau, M Szyf - Journal of Biological …, 2003 - ASBMB
The DNA methylation pattern is an important component of the epigenome that regulates
and maintains gene expression programs. In this paper, we test the hypothesis that …
and maintains gene expression programs. In this paper, we test the hypothesis that …
Establishment and functional validation of a structural homology model for human DNA methyltransferase 1
P Siedlecki, RG Boy, S Comagic… - Biochemical and …, 2003 - Elsevier
Changes in DNA methylation patterns play an important role in tumorigenesis. The DNA
methyltransferase 1 (DNMT1) protein represents a major DNA methyltransferase activity in …
methyltransferase 1 (DNMT1) protein represents a major DNA methyltransferase activity in …
DNA Hypermethylation in Drosophila melanogaster Causes Irregular Chromosome Condensation and Dysregulation of Epigenetic Histone Modifications
F Weissmann, I Muyrers-Chen, T Musch… - … and cellular biology, 2003 - Taylor & Francis
The level of genomic DNA methylation plays an important role in development and disease.
In order to establish an experimental system for the functional analysis of genome-wide …
In order to establish an experimental system for the functional analysis of genome-wide …
De novo DNA methylation at the CpG island of the zebrafish no tail gene
K Yamakoshi, N Shimoda - genesis, 2003 - Wiley Online Library
The zebrafish no tail gene (ntl) is indispensable for the formation of the notochord and the
tail structure. Here we showed that de novo DNA methylation occurred at the CpG island of …
tail structure. Here we showed that de novo DNA methylation occurred at the CpG island of …
Duplication-dependent CG suppression of the seed storage protein genes of maize
This study investigates the prevalence of CG and CNG suppression in single-vs. multicopy
DNA regions of the maize genome. The analysis includes the single-and multicopy seed …
DNA regions of the maize genome. The analysis includes the single-and multicopy seed …
[PDF][PDF] Epigenetic modifications associated with the maternal and paternal alleles of necdin, an imprinted gene in the Prader-Willi Syndrome region
ML Hanel - 2003 - era.library.ualberta.ca
The human neurobehavioural disorder Prader-Willi Syndrome (PWS) results from loss of the
paternal complement of the chromosome region 15qll-ql3. An imprinting centre (IC) controls …
paternal complement of the chromosome region 15qll-ql3. An imprinting centre (IC) controls …
[图书][B] Genetic and epigenetic impact of allopolyploidization in wheat
K Kashkush - 2003 - search.proquest.com
It has long been suggested that gene and genome duplication have played important roles
in the evolution of organismal complexity. In recent years, the events that affect the genome …
in the evolution of organismal complexity. In recent years, the events that affect the genome …