Causative and susceptibility genes for Alzheimer's disease: a review
A Rocchi, S Pellegrini, G Siciliano, L Murri - Brain research bulletin, 2003 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia in the elderly population.
Three genes have been identified as responsible for the rare early-onset familial form of the …
Three genes have been identified as responsible for the rare early-onset familial form of the …
Pathogenesis of cerebral amyloid angiopathy
AAM Rensink, RMW de Waal, B Kremer… - Brain Research …, 2003 - Elsevier
Cerebral amyloid angiopathy (CAA) is the result of the deposition of an amyloidogenic
protein in cortical and leptomeningeal vessels. The most common type of CAA is caused by …
protein in cortical and leptomeningeal vessels. The most common type of CAA is caused by …
Early onset familial Alzheimer's disease: mutation frequency in 31 families
JC Janssen, JA Beck, TA Campbell, A Dickinson… - Neurology, 2003 - AAN Enterprises
Background: Three causative genes have been identified for autosomal dominant AD.
Objective: To determine the proportion of patients with early onset AD with a positive family …
Objective: To determine the proportion of patients with early onset AD with a positive family …
Truncated beta‐amyloid peptide species in pre‐clinical Alzheimer's disease as new targets for the vaccination approach
N Sergeant, S Bombois, A Ghestem… - Journal of …, 2003 - Wiley Online Library
Vaccination against human beta‐amyloid peptide (Aβ) has been shown to remove the
amyloid burden produced in transgenic mice overexpressing the mutated human amyloid …
amyloid burden produced in transgenic mice overexpressing the mutated human amyloid …
Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland
C Żekanowski, M Styczyńska, B Pepłońska… - Experimental …, 2003 - Elsevier
Mutations in three causative genes have been identified in patients with an autosomal-
dominant form of early-onset Alzheimer's disease (EOAD). To determine the spectrum of …
dominant form of early-onset Alzheimer's disease (EOAD). To determine the spectrum of …
In vitro models of age-related neurodegenerative disorders
A Delacourte, N Sergeant, L Buée - Experimental gerontology, 2003 - Elsevier
Aging is the major risk factor for numerous brain diseases. This is especially true for
Alzheimer's disease (AD), a peculiar neurodegenerative disorder in that it results from the …
Alzheimer's disease (AD), a peculiar neurodegenerative disorder in that it results from the …
[图书][B] Familial Alzheimer's disease mutations decrease gamma-secretase processing of beta amyloid precursor protein
JC Wiley - 2003 - search.proquest.com
Gamma-secretase mediated cleavage of the β-secretase processed β-amyloid precursor
protein leads to the extracellular release of Aβ40 and Aβ42, the more amyloidogenic form of …
protein leads to the extracellular release of Aβ40 and Aβ42, the more amyloidogenic form of …
[引用][C] Novel APP mutation V715A associated with presenile Alzheimer's disease in a German family
Novel APP mutation V715A associated with presenile Alzheimer’s disease in a German
family LETTER TO THE EDITORS Page 1 J Neurol (2003) 250 : 1374 –1375 DOI 10.1007/s00415-003-0182-5 …
family LETTER TO THE EDITORS Page 1 J Neurol (2003) 250 : 1374 –1375 DOI 10.1007/s00415-003-0182-5 …