Histone acetyltransferases and histone deacetylases regulate the acetylation of histones
and transcription factors, and in doing so have major roles in the control of cell fate. Many …

Many recent findings have altered our vision of chromatin and its role in the regulation of
cellular functions. Our perspective concerning chromatin has changed to a much more …

Microtubules are cylindrical cytoskeletal structures found in almost all eukaryotic cell types
which are involved in a great variety of cellular processes. Reversible acetylation on the ϵ …

Purpose: Antineoplastic drugs belonging to platinum or taxane families are severely
neurotoxic, inducing the onset of disabling peripheral neuropathies with different clinical …

Alterations in the differentiated state of vascular smooth muscle cells (SMCs) are known to
play a key role in vascular diseases, yet the mechanisms controlling SMC differentiation are …

Transcriptional activation is associated commonly with recruitment of histone acetylases,
while repression involves histone deacetylases (HDACs). Here, we provide evidence to …

Disruption of one copy of the human CREB binding protein (CBP or CREBBP) gene leads to
the Rubinstein–Taybi syndrome (RTS), a developmental disorder characterized by retarded …

The expression of many cellular genes is modulated by DNA methylation and histone
acetylation. These processes can influence malignant cell transformation and are also …

To isolate proteins involved in hTERT transcriptional regulation, the HeLa cDNA library was
screened using the hTERT promoter-based yeast one-hybrid assay. A positive clone was …

The fate of the cell relies on a delicate balance between gene expression and repression.
The transcriptional control of the genome is maintained not only by transcription factors but …