Women are protected from stroke in their early years relative to men. This native
neuroprotection is lost within ten years of the menopause, an observation commonly …

The enzyme aromatase catalyzes the conversion of testosterone and other C19 steroids to
estradiol. Under normal circumstances, the expression of aromatase in the central nervous …

We examined the mechanism of 17β-estradiol (estrogen)-mediated inhibition of apoptosis in
C6 (rat glioma) cells following exposure to hydrogen peroxide (H2O2). Cells were …

Clinical studies suggest that estrogen may improve cognition in Alzheimer's patients. Basic
experiments demonstrate that 17β‐estradiol protects against neurodegeneration in both cell …

The following review is a brief discussion about spinal cord injury and the possibility of using
estrogen as a neuroprotective agent. There are several pathways by which secondary cell …

The neuregulin glial growth factor 2 (GGF2) is a neural growth factor that is best known for its
ability to promote the survival and proliferation of oligodendrocytes and Schwann cells …

Estrogen attenuates neural damage resulting from a variety of experimental injury models in
adult female rats. To determine whether estrogens neuroprotective actions are age-specific …

The original neuroprotective hypothesis of estrogen was based on the gender difference in
brain response to the ischemia-reperfusion injury. Additional clinical reports also suggest …

Multiple sclerosis (MS) occurs more commonly in females than males. However, the
mechanisms resulting in gender differences in MS are unknown. Several studies have …

Corneal infection with herpes simplex virus (HSV) leads to the recruitment of immune cells to
the eye itself, the trigeminal ganglion and the brainstem. In addition, some resident cells in …